Study summary · research use only
[Epigenetic aspects of peptidergic regulation of vascular endothelial cell proliferation during aging]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study using tissue-specific and dissociated vascular endothelial cell cultures from young and old animals (species not stated in the abstract), the authors examined the short peptides vesugen and D-7. The abstract reports both peptides stimulated proliferation-associated protein Ki-67, which declines with aging, and that molecular docking indicated the peptides interacted with the promoter region of the MKI67 gene encoding Ki-67, contacting a core promoter sequence located from -14 to +12 base pairs relative to the transcription initiation site through the CATC sequence. The authors suggest vesugen's vasoprotective effect could be realized through epigenetic regulation of Ki-67 gene expression.
Abstract
Short peptides vesugen and D-7 have stimulated proliferation-associated protein Ki-67 decreased during aging in tissue-specific cell cultures received from young and old animals and in dissociated vascular endothelial cell cultures. Peptides vesugen and D-7 have interacted with promoter region of MKI67 gene coding protein Ki-67 that was obtained using methods of molecular docking. Both peptides have contacted with core promoter 5'-agcctcaaccatcaggaaaacaagagt-3' located in MKI67 gene from -14 to +12 base pairs relative to the transcriptional initiation site through sequence CATC(ENSG00000148773). Thus, vasoprotective effect of peptide vesugen revealed previously in elder people could be realized through epigenetic regulation of Ki-67 gene expression.
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