Study summary · research use only
We are ageing
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review analyzes mechanisms and theories of ageing and longevity. The abstract lists proposed pathways involving oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, the growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure. It states that among the leads for longevity discussed are caloric restriction, target of rapamycin (TOR), sirtuins, hexarelin, and hormetic responses.
Abstract
Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also, some theories of ageing were introduced. To date, the most promising leads for longevity are caloric restriction, particularly target of rapamycin (TOR), sirtuins, hexarelin and hormetic responses. This review is an attempt to analyze the mechanisms and theories of ageing and achieving longevity.
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