Study summary · research use only
Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This in vitro study examined cultured human and rat thymic cells to investigate immunomodulating effects of two dipeptides, AB-O and R-1. Both dipeptides were shown to increase expression of the lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cell precursor differentiation toward CD4(+) T-helpers, with an effect weaker than that of dipeptide R-1, while dipeptide R-1 stimulated differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells, leading the authors to describe it as a bioactive substance possessing immunomodulator and antiallergic activity.
Abstract
We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cells precursor differentiation towards CD4(+)T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.
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