Study summary · research use only
Collagen stimulating effect of peptide amphiphile C16-KTTKS on human fibroblasts
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This in vitro study examined collagen production by human dermal and corneal fibroblasts exposed to the peptide amphiphile (PA) C16-KTTKS, used in antiwrinkle cosmeceutical applications (trade name Matrixyl), and related this to the PA's self-assembly into nanotape structures, assessed via pyrene fluorescence spectroscopy. The authors reported that C16-KTTKS stimulated collagen production in a concentration-dependent manner, close to the critical aggregation concentration, suggesting that self-assembly and stimulation of collagen production are inter-related.
Abstract
The collagen production of human dermal and corneal fibroblasts in contact with solutions of the peptide amphiphile (PA) C16-KTTKS is investigated and related to its self-assembly into nanotape structures. This PA is used in antiwrinkle cosmeceutical applications (trade name Matrixyl). We prove that C16-KTTKS stimulates collagen production in a concentration-dependent manner close to the critical aggregation concentration determined from pyrene fluorescence spectroscopy. This suggests that self-assembly and the stimulation of collagen production are inter-related.
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