Study summary · research use only
[The immunocorrective therapy of pyoderma caused by staphylococci multiply resistant to antibiotics]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined 126 human patients with staphylococcal pyodermas caused by antibiotic-multiresistant staphylococci, relating total antibiotic sensitivity of isolated staphylococci to markers of immune status (blood T-lymphocyte levels, leukocyte migration inhibition test sensitization, and IgM/IgG ratio). The synthetic thymus preparation thymogen was reported to have a modulating effect on lymphocytes, increasing total T-lymphocyte and T-helper counts. In 23 patients with chronic pyodermas, a course of thymogen therapy was associated with reduced total antibiotic resistance of the agent at skin infection sites and normalization of immunologic reactivity parameters. The authors describe a combination of thymogen with antibiotics as a management approach for chronic pyoderma.
Abstract
Examinations of 126 patients with staphylococcal pyodermas have helped detect a relationship between the total antibiotic sensitivity of staphylococci isolated from the involved skin and the patient's immunity status. The total antibiotic sensitivity of staphylococci in directly proportional to the blood level of T-lymphocytes, to the degree of their sensitization to staphylococcus in the leukocyte migration inhibition test, and to the value of IgM/IgG ratio. A new synthetic preparation of thymus, thymogen, had a modulating effect on the lymphocytes of pyoderma patients, manifesting by the increment of the total count of T-lymphocytes and T-helpers. A reduction of the total antibiotic resistance of the agent in foci of skin infection and normalization of the immunologic reactivity parameters were recorded in 23 patients with chronic pyodermas after a course of thymogen therapy. An effective method for the management of chronic pyoderma by a combination of thymogen with antibiotics is suggested.
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