Study summary · research use only
The emerging role of the mitochondrial-derived peptide humanin in stress resistance
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the mitochondrial-derived peptide humanin and its emerging role in stress resistance (species not specified). The authors describe that humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro, and has been reported to improve outcomes in models of cardiovascular disease as well as Alzheimer's disease in vivo. The review summarizes humanin's proposed mechanism of action and its potential pharmacological relevance.
Abstract
The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.
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