Study summary · research use only
[Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This in vitro study examined chromatin in cells from human individuals aged 75-86 years exposed to the oligopeptide bioregulator Prostamax (Lys-Glu-Asp-Pro), evaluating sister chromatid exchange (SCE) frequency, Ag-positive NORs, and pericentromeric heterochromatin structure. The authors reported that Prostamax increased SCE frequency to 12,0±0,28 exchanges per cell (versus 5,9±0,2 in intact cells), increased Ag-positive NORs to 2.5 per cell (versus 0.95), and reduced the frequency of large pericentromeric heterochromatin segments for the 1st and 9th chromosomes. The authors concluded these findings indicate decondensation and deheterochromatinization of chromatin during aging, potentially releasing genes repressed by heterochromatinization, and suggested this modifying effect on chromatin underlies Prostamax's protective action.
Abstract
In this work is presented the data on the variability of the functional characteristics of the chromosomes in the cells exposed by oligopeptide bioregulator - Prostamax from old individuals (75-86 years). Evaluated: the frequency of sister chromatid exchanges (SCE); Ag-positive NORs (in associations and nonassociations), as well as the variability of the structural C-pericentromeric heterochromatin. Prostamax changed the chromosomal parameters: 1) increased the frequency of SCE to 12,0±0,28 exchange in per cell (in intact cells - 5,9±0,2); 2) increased the frequency of Ag-positive NORs to 2.5 per cell (in intact cells - 0.95) 3) reduced in the frequency of large segments of the options from the pericentromeric heterochromatin for the 1st and 9th chromosomes. Comparison of the results indicates the ability of Prostamax to decondensation, deheterchromatinization the chromatin during aging, and thus release by heterochromatinization repressed genes. On the other hand, the data obtained in this work suggest that the basis for the protective action of Prostamax its modifying effect on chromatin.
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