Study summary · research use only
Prospects of using pancragen for correction of metabolic disorders in elderly people
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study examined two groups of older individuals, 30 healthy and 33 patients with type 2 diabetes mellitus, to assess melatonin production and the effect of pancragen on metabolic parameters. Nocturnal melatonin production was reported to be reduced by 70% in patients with type 2 diabetes compared with healthy individuals of similar age. In patients with type 2 diabetes, pancragen was associated with decreased fasting glucose, decreased glucose levels on a standard glucose tolerance test, and reduced plasma insulin and insulin resistance index, while no changes in carbohydrate metabolism indices were observed in patients not receiving pancragen. The authors describe the tetrapeptide pancragen as an approach to correcting insulin resistance in this population.
Abstract
We examined two groups of older persons: 30 healthy and 33 patients with type 2 diabetes mellitius. Nocturnal melatonin production was significantly reduced by 70% in patients with DM2 compared to healthy individuals of the corresponding age. In patients with DM2, pancragen significantly decreased glucose level on an empty stomach and in standard glucose tolerance test and reduced plasma concentrations of insulin and insulin resistance index. In patients receiving no pancragen, no changes in carbohydrate metabolism indices were observed. Thus, disturbances in the melatonin-producing function of the pineal gland in elderly individuals contribute to the development of insulin resistance. Administration of the tetrapeptide pancragen is a promising approach to the correction of insulin resistance in elderly individuals.
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