Study summary · research use only
Vasoactive intestinal peptide: a neuropeptide with pleiotropic immune functions
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter distributed throughout the central and peripheral nervous system and released by neurons and immune cells. It describes VIP's production and effects on immune cells, VIP receptor signaling as it relates to immune function, and its involvement in inflammatory and autoimmune disorders, along with pleiotropic roles as a neurotransmitter, immune regulator, vasodilator, and secretagogue. The review addresses current clinical use of VIP and discusses possible future therapeutic directions.
Abstract
Vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide/neurotransmitter, is widely distributed in both the central and peripheral nervous system. VIP is released by both neurons and immune cells. Various cell types, including immune cells, express VIP receptors. VIP has pleiotropic effects as a neurotransmitter, immune regulator, vasodilator and secretagogue. This review is focused on VIP production and effects on immune cells, VIP receptor signaling as related to immune functions, and the involvement of VIP in inflammatory and autoimmune disorders. The review addresses present clinical use of VIP and future therapeutic directions.
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