Study summary · research use only
Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this mouse study, researchers examined the effect of the tuftsin analog Selank and two of its fragments on expression of 84 genes involved in inflammation in the spleen, measured 6 and 24 h after a single intraperitoneal injection of Selank (100 μg/kg) using real-time PCR. The abstract reports significant changes in the expression of 34 genes, including consistent changes in the Bcl6 gene and its target and corepressor genes in response to each peptide. The authors state these findings support a role for Selank in regulating inflammation-related gene expression, possibly through systemic effects on genomic expression.
Abstract
Previous studies have shown that synthetic tuftsin analogue Selank causes a transcriptomic response in the rat hippocampus and in spleen cells and may participate in the regulation of inflammatory processes in the body. In this work we studied the effect of Selank and two of its fragments on the expression of genes involved in processes of inflammation. We analyzed the expression of 84 genes involved in processes of inflammation (e.g., chemokines, cytokines, and its receptors) in mouse spleen 6 and 24 h after Selank single intraperitoneal injection (100 μg/kg) using real-time PCR method. We found significant changes in the expression of 34 genes involved in inflammation processes. The detailed analysis of quantitative data showed that the Bcl6 gene, which plays a main role in the formation and development of the immune system, exhibited significant changes in its expression levels in response to injection of each of the peptides. Also, we observed expression changes for Bcl6 target and corepressor genes under the influence of Selank and its fragments. Our results showed that Selank and its fragments caused a number of alterations in the expression of genes involved in inflammation. The data obtained confirmed the participation of Selank in the processes of regulation of inflammation in the body. The complex biological effect of Selank may be partially determined by the systematic effect of this peptide on genomic expression.
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