Study summary · research use only
[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This rat study examined effects of the polypeptide drug cortexin and the synthetic peptide drug cortagen on functional and metabolic disturbances in chronic brain ischemia, comparing rats with high and low resistance to hypoxia. Both drugs were reported to accelerate recovery of disturbed individual behavior in ischemic rats of both resistance types, and to prevent excessive activation of lipid peroxidation and a decrease in antioxidant activity in brain tissue. The authors concluded cortexin and cortagen could be used to increase the effect of neuroprotective therapy in cases of chronic brain ischemia.
Abstract
The polypeptide drug cortexin and the synthetic peptide drug cortagen accelerate the recovery of disturbed individual behavior of ischemic rats with different resistance to hypoxia (high and low resistant rats). In addition, both drugs prevented an excessive activation of lipid peroxidation and a decrease in the antioxidant activity in the brain tissues. The obtained results suggest that cortexin and cortagen can be used for increasing the efficacy of neuroprotective therapy in cases of chronic brain ischemia.
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