Study summary · research use only
Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study examined effects of the Mechano Growth Factor E peptide (MGF-E), derived from an IGF-1 isoform, on human muscle progenitor cells isolated from healthy subjects of different ages. The MGF-24aa-E peptide was reported to increase the proliferative life span and delay senescence of satellite cells from neonatal and young adult, but not old adult, muscle, with hypertrophy associated with a decreased percentage of reserve cells observed across all cultures. The authors concluded MGF-24aa-E peptide enhances satellite cell activation, proliferation, and fusion for muscle repair and maintenance, and proposed it as a potential strategy for age-related sarcopenia without the oncogenic side effects reported for IGF-1.
Abstract
Loss of muscle mass and strength is a major problem during aging and the expression of Mechano Growth Factor (MGF), a member of the IGF-1 (insulin-like Growth Factor 1) super family, has been shown to be both exercise and age dependent. MGF, also called IGF-1Ec, has a unique E domain with a 49bp insert in humans (52bp in rodents; IGF-1Eb), which results in a reading frame shift during the IGF-1 gene splicing to produce a distinct mature isoform. We have studied the effects of the MGF-24aa-E peptide on proliferation and differentiation of primary human muscle cell cultures isolated from healthy subjects of different ages. We found that MGF-E peptide significantly increases the proliferative life span and delays senescence of satellite cells isolated from neonatal and young adult but not from old adult muscle, hypertrophy associated with a significant decrease in the percentage of reserve cells was observed in all cultures. It is concluded that the MGF-24aa-E peptide alone has a marked ability to enhance satellite cell activation, proliferation and fusion for muscle repair and maintenance and could provide a new strategy to combat age related sarcopenia without the oncogenic side effects observed for IGF1.
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