Study summary · research use only
Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This case report describes analysis of an unknown pharmaceutical preparation submitted by Norwegian police and customs authorities in 2009, using liquid chromatography-high resolution tandem mass spectrometry (LC-HRMS/MS). The preparation was found to contain a 29 amino acid peptide with a C-terminal amide function, and interpretation of the mass spectrometric data yielded a sequence consistent with the peptide marketed as CJC-1295, a growth-hormone-releasing peptide. The authors note CJC-1295 is listed as a Prohibited Substance under Section S2 of the WADA Prohibited List, describe it as having potential performance-enhancing effects and being readily available, and state there is reason to believe it is used within the bodybuilding community.
Abstract
Several peptide drugs are being manufactured illicitly, and in some cases they are being made available to the public before entering or completing clinical trials. At the request of Norwegian police and customs authorities, unknown pharmaceutical preparations suspected to contain peptide drugs are regularly subjected to analysis. In 2009, an unknown pharmaceutical preparation was submitted for analysis by liquid chromatography-high resolution tandem mass spectrometry (LC-HRMS/MS). The preparation was found to contain a 29 amino acid peptide with a C-terminal amide function. Based on the interpretation of mass spectrometric data, an amino acid sequence was proposed. The sequence is consistent with a peptide currently marketed under the name CJC-1295. CJC-1295 is a releasing factor for growth hormone and is therefore considered a Prohibited Substance under Section S2 of the WADA Prohibited List. This substance has potential performance-enhancing effects, it is readily available, and there is reason to believe that it is being used within the bodybuilding community.
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