Study summary · research use only
[The effect of thymogen on the cell division processes in the corneal epithelium under physiological conditions and in an experimental thermal burn]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This rat study (140 rats, 280 eyes) examined effects of the preparation thymogene on corneal epithelial cell division under normal physiological conditions and after experimental thermal burn to the eye. In intact animals, the preparation was reported to stimulate DNA synthesis with both systemic and local administration, most pronounced by the 3d-5th day after administration. In rats with corneal burns, thymogene administration was reported to stimulate cellular proliferation in the corneal epithelium both early (day 3) and later (day 14) after burn injury. The authors described thymogene as a candidate preparation warranting further study for corneal healing after burn trauma.
Abstract
Experimental studies of the influence of a new pharmacologic preparation thymogene on the processes of cellular multiplication of the corneal epithelium in physiologic conditions and thermic burn of the eye in 140 rats. (280 eyes) have shown that in intact animals the preparation produces DNA synthesis in both systemic and local usage, that is most expressed by the 3d-5th day after its administration. The study of the influence of thymogene on reparative processes in rats with corneal burns has shown that administration of the preparation stimulates processes of cellular population in the corneal epithelium both in the early period (on the 3d day) and by the 14th day after burn trauma. This allows to consider thymogene a perspective preparation for a quicker healing of the cornea after burn trauma.
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