Study summary · research use only
Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This single-dose, randomized, double-blind, crossover human trial evaluated the abuse-related effects of tesofensine (a triple reuptake inhibitor of noradrenaline, dopamine, and serotonin in development for obesity) compared with placebo, D-amphetamine, bupropion, and atomoxetine in 52 recreational stimulant users. Subjective and objective measures were assessed for 48 h after drug administration. D-amphetamine effects were reported as significantly greater than placebo on subjective measures, while tesofensine effects were not significantly different from placebo and were lower than D-amphetamine 30 mg on most measures. Tesofensine effects were also lower than or not different from bupropion or atomoxetine. The authors concluded the abuse potential of tesofensine was no greater than that of bupropion or atomoxetine.
Abstract
Tesofensine is a (triple) reuptake inhibitor of noradrenaline, dopamine, and serotonin that is in development for the treatment of obesity. The abuse potential of triple reuptake inhibitors is not yet known, and so this study was undertaken to evaluate the potential abuse-related effects of tesofensine in humans. It was designed as a single-dose, randomized, double-blind, crossover study involving tesofensine vs. placebo, D-amphetamine (positive control for dopaminergic/stimulant effects), bupropion, and atomoxetine (negative/unscheduled controls) in recreational stimulant users (N = 52). Subjective and objective measures were assessed for 48 h after drug administration. The study results show that the effects of D-amphetamine were significantly greater than those of placebo on all primary and secondary subjective measures. The effects of tesofensine were not significantly different from those of placebo and were lower than those of D-amphetamine 30 mg on all primary and most secondary measures. The effects of tesofensine were either lower than or not different from those of bupropion or atomoxetine. These results demonstrate that the abuse potential for tesofensine is no greater than that of bupropion or atomoxetine, and tesofensine is therefore unlikely to be recreationally abused.
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