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Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the authors examined the tumor-modifying effect of cardiogen peptide on transplanted M-1 sarcoma in senescent rats. The abstract reports that the level of tumor cell apoptosis after cardiogen injections in all experimental groups was higher than in the control, and that dose-dependent inhibition of M-1 sarcoma growth after cardiogen injection was associated with the development of hemorrhagic necrosis and stimulation of tumor cell apoptosis. The authors state that proliferative activity parameters indicated the growth inhibition was not caused by a direct cytostatic effect of the drug on the tumor, and that morphological signs indicated a specific mechanism of cardiogen action realized through the vascular network of the tumor. No summary numerical results were provided in the abstract.
Abstract
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma. The level of apoptosis of tumor cells after cardiogen injections in all experimental groups was higher than in the control. The dose-dependent inhibition of M-1 sarcoma growth after injection of cardiogen was caused by the development of hemorrhagic necrosis and stimulation of tumor cell apoptosis. The parameters of proliferative activity indicate that inhibition of tumor growth was not caused by the direct cytostatic effect of the drug on the tumor. Morphological signs indicate a specific mechanism of cardiogen action, realized through the vascular network of the tumor.
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