Study summary · research use only
[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the authors examined the effect of 20 amino acids and the synthetic tetrapeptide cardiogen (concentration 10^-12 M) on cell proliferation and apoptosis in myocardial tissue explants from 3- and 24-month-old rats, using organotypic tissue culture. The abstract reports that 7 of 20 amino acids stimulated cell proliferation in tissue from young rats, whereas only 2 amino acids were active in myocardial culture from old rats. The tetrapeptide cardiogen was described as demonstrating a stimulating effect on proliferation in tissues from both young and old rats. Immunohistochemistry showed a decrease of p53 protein expression under cardiogen, which the authors interpret as evidence that cardiogen inhibits the apoptosis process in myocardial tissue.
Abstract
The effect of 20 amino acids and the synthetic tetrapeptide cardiogen in concentration 10(-12) M was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in myocard tissue explant in 3- and 24-months old rats. 7 of 20 amino acids stimulated the cell proliferation in the young rats. In the same time, only 2 amino acids were active in myocard culture from the old rats. The tetrapeptide cardiogen demonstrated the great stimulating effect on the proliferation both in tissues from young and old rats. The immunohistochemical study demonstrated a decrease of the p53 protein expression by cardiogen action. This fact can testify that cardiogen inhibits the apoptosis process in the myocard tissue.
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