Study summary · research use only
Synthetic and natural immunomodulators acting as interferon inducers
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses synthetic and natural immunomodulators acting as interferon inducers (human/clinical context). The authors describe interferons as immunomodulatory molecules with antiviral, antibacterial, antitumor, and inflammatory activities, and note that natural and recombinant interferons are among the most common biologic therapeutics. They state that interferon inducers are less known and were mostly developed and used in former socialist countries, representing a substantial market share of the pharmacopoeia there while being largely unknown in the Western world. The review provides brief descriptions of many interferon inducers, including Amyxin, Amizon, Arbidol, Cycloferon, Galavit, Kagocel, Likopid, Neovir, Thymogen, and others, some in use for decades for the same indications as interferons. The article calls attention to these agents rather than presenting new experimental data. No numerical results are reported.
Abstract
Interferons are first immunomodulatory molecules that have been shown to display a wide range of applications due to their antiviral, antibacterial, antitumor, and inflammatory activities. Natural and recombinant interferons are among most common biologic therapeutics worldwide. Interferon inducers, however, are less known and have been mostly developed and used in former socialist countries. Despite the fact that they are virtually unknown to the Western world, they represent a substantial market share of modern pharmacopoeia in former socialist republics. This review provides a brief description of most popular interferon inducers including Amyxin, Amizon, Anandin, Arbidol, Blasten, Cycloferon, Galavit, Groprinosine, Hepon, Immunoxel, Dzherelo, Kagocel, Larifan, Ligfol, Likopid, Mebavin, MIGI-KLP, V-5 Immunitor, SCV-07, Milife, Neovir, Poludan, Ragocin, Ridostin, Thymogen and Savratz, some of which were in use for several decades for the same clinical indications as for interferons. The variety and choice offered by the pharmaceutical industry behind the former "iron curtain" certainly deserves the appreciation, familiarity and application prospects for medical and research investigators worldwide.
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