Study summary · research use only
Age-dependent experimental tumor dissemination of murine melanoma B16
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this mouse study, female C57BL/6 Jena mice aged 3, 12, and 18 months were inoculated intravenously with syngeneic melanoma B16 cells. Experimental lung metastases counted 21 days after inoculation were significantly higher in older hosts. The abstract reports that pretreatment of young adult mice with an immunosuppressive dose of cyclophosphamide considerably increased lung nodules, and that the number of lung metastases was reduced when young and old animals were pretreated or treated with Poly (I:C). Similar treatment with two other immunomodulators (thymalin and diacetyl-splenopentin 5) was reported as practically without effect on metastasis formation. The authors suggest the higher number of experimental metastases in aged mice is mediated by immuno-senescence.
Abstract
Female C57BL/6 Jena mice, 3-, 12-, and 18-month-old, were inoculated intravenously (i.v.) with syngeneic melanoma B16 cells. The number of experimental lung metastases, counted 21 days after tumor inoculation, was significantly higher in older hosts. Pretreatment of young adult mice with immunosuppressive dose of cyclophosphamide considerably increased the number of lung nodules. The number of lung metastases was reduced when young and old animals were pretreated or treated with Poly (I:C). Similar treatment of mice with two other immunomodulators (thymalin and diacetyl-splenopentin 5) was practically without effect on metastasis formation. It is suggested that the higher number of experimental metastases of melanoma B16 in aged mice is mediated by immuno-senescence.
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