Study summary · research use only
Hexarelin Signaling to PPARgamma in Metabolic Diseases
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review discusses the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) and its regulation by growth hormone releasing peptides such as hexarelin in metabolic disease (no specific species; discussion of molecular pathways). The authors summarize the biologic roles and mechanism of PPARgamma in transcriptional control of lipid and glucose metabolism and note that thiazolidinediones regulate PPARgamma and exhibit insulin-sensitizing effects in diabetes treatment. They review evidence that growth hormone releasing peptides regulate PPARgamma through interaction with the scavenger receptor CD36 and the ghrelin GHS-R1a receptor, and discuss the impact of these peptides on lipid metabolism and energy homeostasis. The authors express hope that novel approaches to regulating PPAR functions will add therapeutic possibilities for metabolic diseases. No experimental outcomes or numerical data are presented.
Abstract
Investigating the metabolic functions of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has been extremely rewarding over the past years. Uncovering the biologic roles of PPARgamma and its mechanism of action has greatly advanced our understanding of the transcriptional control of lipid and glucose metabolism, and compounds such as thiazolidinediones which directly regulate PPARgamma have proven to exhibit potent insulin-sensitizer effects in the treatment of diabetes. We review here recent advances on the emerging role of growth hormone releasing peptides in regulating PPARgamma through interaction with scavenger receptor CD36 and ghrelin GHS-R1a receptor. With the impact that these peptides exert on the metabolic pathways involved in lipid metabolism and energy homeostasis, it is hoped that the development of novel approaches in the regulation of PPAR functions will bring additional therapeutic possibilities to face problems related to metabolic diseases.
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