Study summary · research use only
[Effect of vilon on neuroendocrine status and sexual function of old male rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, the authors used hemigonadectomised male rats as a model of age-related sexual-function decline to examine the dipeptide Vilon on sexual function and neuroendocrine status. They report that regular administration of Vilon (50 microg per rat) was associated with activated sexual function in old male rats and significant changes in neuroendocrine status, including levels of LH, prolactin, and ACTH and hypothalamic neurotransmitter content. The authors interpret the sexual-function changes as mediated by a set of neuroendocrine and neurotransmitter factors rather than a single parameter, and highlight a notable decrease in blood prolactin.
Abstract
The hypogonadal status of hemigonadectomised male rats has been choseh as a model of age-related sexual function decline in animals. The effect of dipeptide Vilon on parameters of sexual function and neuroendocrine status was studied. The results showed that regular introduction of Vilon in a dose of 50 microg per rat activates sexual function in old male rats. The obtained data confirm that Vilon significantly affects neuroendocrine status of animals, as well as the level of LH, prolactin and ACTH and changes the content of neurotransmitters in hypothalamus. We consider the changes in sexual function caused by Vilon not relate to change in one parameter only, but are mediated by a set of neuroendocrine and neuromediatorial factors. Significant decrease in prolactin content in blood is worthy of notice, as age-related hypersecretion of this hormone is one of the main factors leading to age-related sexual function decline.
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