Study summary · research use only
[Effect of thymagen, thymalin and vilosen on the cAMP and cGMP levels and phosphodiesterase activity in spleen lymphocytes during sensitization and anaphylactic shock]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of guinea pigs, the authors examined thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on the cyclic nucleotide system in spleen lymphocytes during sensitization and anaphylactic shock. They report that sensitization was associated with a decreased cAMP/cGMP ratio and that anaphylaxis leveled the ratio toward the reference level. The authors describe increased activity of cyclic-nucleotide catabolism enzymes under the influence of thymogen, thymalin, and vilosen in lymphocytes of sensitized guinea pigs, with a tendency to increase in anaphylaxis-treated animals.
Abstract
It is established that the effect of thymus-derived species is connected with the cyclic nucleotide system. The action of thymus-derived immunocorrectors (thymalin, thymagen, vilosen) on catabolic processes of cyclic nucleotides has been observed under conditions of anaphylaxy and sensibilization. They show that sensibilization of the animal is bound up with a decrease of the cAMP/cGMP ratio. Anaphylaxis induces levelling of the cAMP/cGMP ratio up to the reference level. So, activity of enzymes of cyclic nucleotide catabolism grows due to the influence of thymogen, thymalin and vilosen in lymphocytes of sensibilized guinea pigs and tends to an increase in lymphocytes of anaphylaxis-treated animals.
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