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Thymic endocrinology
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review article discusses thymus endocrinology, describing how various hormones act on the thymic milieu of thymocytes, thymic epithelial cells, and stromal cells. The authors outline extrathymic influences, pituitary prolactin, ACTH via hydrocortisone, thyroid-stimulating hormone via thyroid hormones, and LH/RH via sex steroids, and the thymus's own putative hormones thymosin alpha 1, thymulin, and thymopoietin, which act on prothymocytes and mature T-cells. They note these endocrine influences decline with age (thymic menopause) alongside immune senescence, and describe an intrathymic network of paracrine and autocrine signals involving interleukins and thymic peptides, including the zinc-thymulin complex. The abstract is truncated at 250 words.
Abstract
Thymus endocrinology is characterized by the action of various hormones on the thymus endocrine milieu consisting of thymocytes, thymic epithelial cells and thymic stromal cells. Extrathymic hormonal influences include pituitary-derived hormones, such as prolactin and indirectly by ACTH via hydrocortisone from the adrenal, by thyroid-stimulating hormone (TSH) via thyroid hormones from the thyroid, and by LH and RH via sex steroids from gonads and adrenal. In addition, the thymus produces several putative thymic hormones: thymosin alpha 1, thymulin and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T-cells in the periphery thus maintaining their commitment to the T-cell system and its functions. These endocrine influences decline with age and are associated with "thymic menopause" and cellular immune senescence contributing to the development of diseases in the aged. The intrathymic environment is characterized by a complex network of paracrine and autocrine endocrine signals involving both interleukins and thymic peptides. Thymic epithelial cells respond to IL-1 with proliferation and secretion of IL6 and GM-CSF. They similarly respond to cellular interactions with the production of IL1. Thymic epithelial cells also secrete thymic hormones, as exemplified by the zinc-thymulin complex, under stimulation with IL1 and other hormonal influences. Thymic stromal cells contribute, at minimum, IL1. These various interleukin and thymic hormone influences can be envisioned to operate in a synergistic interactive network to carry the evolving T-cell through its stepwise development to a mature T-cell.(ABSTRACT TRUNCATED AT 250 WORDS)
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