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Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure

Study · animal · Bulletin of experimental biology and medicine · 2005 · DOI 10.1007/s10517-005-0202-9 · PMID 16142267

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

In this rat study, the authors examined the peptide Vilon at 2, 4, and 6 months after the onset of chronic renal failure. They report that subcutaneous Vilon significantly decreased serum transforming growth factor-beta(1) and the permeability of mesenteric microvessels in rats 2 months after onset. The authors interpret this as a homeostatic effect of the preparation in the early period of chronic renal failure.

Abstract

We studied the effect of Vilon in rats 2, 4, and 6 months after the onset of chronic renal failure. Subcutaneous injection of Vilon significantly decreased serum concentration of transforming growth factor-beta(1) and permeability of mesenteric microvessels in rats 2 months after the onset of chronic renal failure. Our results indicate that the preparation produces a potent homeostatic effect in the early period of chronic renal failure.

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