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[Effect of a levopromazine-thymalin combination on the development of toxic edema and swelling in the brain]

Study · animal · Eksperimental'naia i klinicheskaia farmakologiia · 2004 · PMID 15079910

Plain-language summary

Paraphrased from the published abstract below — not a verdict on whether anything works.

In this rat study, the authors examined toxic edematous brain swelling, which they report was accompanied by blood-plasma disproteinemia and an increased gamma-globulin fraction. Administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduced these blood-protein disturbances. The authors describe the antiedematous action of the levopromazine-thymalin combination as an additive synergistic interaction.

Abstract

The development of toxic edematous brain swelling in rats is accompanied by disproteinemia of the blood plasma and buildup of the gamma-globulin fraction. The administration of levopromazine (5 mg/kg), thymalin (1.2 mg/kg), or their combination reduces this disorder in the blood protein fractions. The antiedematous effect of the levopromazine--thymalin combination has an additive synergistic interaction.

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