Study summary · research use only
[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study, mice with transplanted Lewis lung carcinoma and rat spleen tissue explants were used to test the synthetic peptide vilon with the cytostatic cyclophosphan. The authors report that vilon at 1 mg/kg increased survival of tumour-bearing mice, describing an oncomodulating action, whereas simultaneous vilon plus cyclophosphan (100 mg/kg) decreased survival. In spleen organotypic cultures from 1-day-old and 2-year-old rats, vilon stimulated apoptosis in both young and old tissue, and vilon in the culture medium (5 ng/ml) abolished the inhibitory effect of cyclophosphan. The authors suggest vilon and cytostatic drugs should not be used simultaneously.
Abstract
The experiments were performed in mice with transplanted Lewis lung carcinoma. The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice. There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old. Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml. The results obtained suggested that perspective preparates in the cancer therapy--vilon and cytostatic drugs-, must be used not synchronously.
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