Study summary · research use only
Peptides of pineal gland and thymus prolong human life
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This article reports a clinical assessment by Russian and Ukrainian institutes of the geroprotective effects of the thymic peptide Thymalin and pineal peptide Epithalamin in 266 elderly and older people observed over 6-8 years, with the bioregulators applied during the first 2-3 years. The authors describe improvements in cardiovascular, endocrine, immune, and nervous-system indices, homeostasis, and metabolism, a 2.0-2.4-fold decrease in acute respiratory disease incidence, and reduced clinical manifestations of several age-related conditions versus control. They report decreased mortality during observation: 2.0-2.1-fold with Thymalin, 1.6-1.8-fold with Epithalamin, 2.5-fold with both, and 4.1-fold in a group given both annually for 6 years.
Abstract
Researchers of the St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences and the Institute of Gerontology of the Ukrainian Academy of Medical Sciences (Kiev) clinically assessed the geroprotective effects of thymic (Thymalin) and pineal (Epithalamin) peptide bioregulators in 266 elderly and older persons during 6-8 years. The bioregulators were applied for the first 2-3 years of observation. The obtained results convincingly showed the ability of the bioregulators to normalize the basic functions of the human organism, i.e. to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism. Homeostasis restoration was accompanied by a 2.0-2.4-fold decrease in acute respiratory disease incidence, reduced incidence of the clinical manifestations of ischemic heart disease, hypertension disease, deforming osteoarthrosis and osteoporosis as compared to the control. Such a significant improvement in the health state of the peptide-treated patients correlated with decreased mortality rate during observation: 2.0-2.1-fold in the Thymalin-treated group; 1.6-1.8-fold in the Epithalamin-treated group; 2.5-fold in the patients treated with Thymalin plus Epithalamin as compared to the control. A separate group of patients was treated with Thymalin in combination with Epithalamin annually for 6 years and their mortality rate decreased 4.1 times as compared to the control. The obtained data confirmed the high geroprotective efficacy of Thymalin and Epithalamin and the expediency of their application in medicine and social care for health maintenance and age-related pathology prevention in persons over 60 to prolong their active longevity.
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