Study summary · research use only
[Immunomodulation in dystrophic diseases of the joints]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This article describes immunological examinations of 357 patients with mixed arthritis, coxarthrosis, and aseptic necrosis of the femoral head. The authors report immunopathological deviations, including inhibition or dysfunction of T- and B-cell reactions, inversion of a regulatory index, an autoimmune component, and bacterial sensitization in many patients. Alongside conventional immunomodulating agents (levamisole, thymalin, T-activin, sodium nucleinate), they suggest individualized in vitro selection of hemodes and polyglucin. Using ELISA, they describe a strong correlation between antibodies to a glycolipid cartilaginous antigen and arteparon, and a decrease in antibody numbers during arteparon administration, which they interpret as pointing to a hapten-inhibition mechanism.
Abstract
Immunological examinations of 357 patients with mixed arthritis, coxarthrosis and aseptic necrosis of the femoral head have revealed substantial immunopathological deviations requiring immunomodulation and influencing surgical outcomes, with inhibition or dysfunction of T and B cellular reactions, inversion of the regulatory index, remarkable autoimmune component, and bacterial sensitization in a considerable part of the examined. In addition to the conventional immunomodulating agents (levamisole, thymalin, T-activin, sodium nucleinate), it is recommended that hemodes and polyglucin may be used, provided they are chosen individually in vitro. The use of ELISA made it possible to reveal a direct strong correlation between the level of antibodies to glycolipid cartilaginous antigen and arteparon as well as a decrease of the number of antibodies in therapeutic administration of the drug. This suggests the immunological mechanisms of the action of arteparon, namely according to the principle of hapten inhibition.
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