Study summary · research use only
[The effect of the synthetic immunomodulator thymogen on radiation-induced carcinogenesis in rats]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this rat study, female rats received Sr-90 and Cs-137 in drinking water (0.1 and 0.2 microCi/day per animal) over 12 months, with some also given monthly 5-day courses of the synthetic dipeptide thymogen (5 micrograms/animal). The authors report that radionuclide-treated rats had higher overall tumour occurrence and more breast adenocarcinoma, and that thymogen was associated with lower total tumour and cancer occurrence in irradiated animals. Rats given thymogen alone were described as having longer life span, slower aging, and lower tumour and cancer occurrence. The authors state this was the first demonstration of thymogen inhibiting spontaneous and radionuclide-induced carcinogenesis in female rats.
Abstract
Five month-old female rats were given a mixture of Sr-90 and Cs-137 in drinking water in the dose of 0.1 and 0.2 microCi/day per animal over 12 months. Some animals received 12 monthly courses of a synthetic immunomodulating dipeptide--thymogen in the dose of 5 micrograms/animal for 5 consecutive days. Radionuclide-treated rats showed higher occurrence of tumors on the whole and of breast adenocarcinoma, in particular. Thymogen was shown to inhibit Sr-90- and Cs-137-induced radiation carcinogenesis, namely, a decrease in the total tumor and cancer occurrence was observed. The animals receiving thymogen alone showed longer life span, slower rate of aging and lower overall tumor and cancer occurrence. In this study, the ability of a synthetic peptide immunomodulator--thymogen to inhibit spontaneous and radionuclide-induced carcinogenesis in female rats was first established.
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