Study summary · research use only
Modern Immunotherapy in Clinical Medicine: Present and Future
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This review surveys immunotropic preparations used across fields of clinical medicine, including thymus-derived preparations (tactivin, thymalin, thymoptin, thymogen, thymomodulin, thymostimulin, thymopentin/TP-5, and others), synthetic imidazole compounds, IgM/IgG immunoglobulin isotypes, interferon therapy, and cytokine-network-directed approaches such as cytokine replacement, therapeutic cytokine administration, and monoclonal antibodies against cytokines or their receptors. The author notes that cytokine use in tumor processes is among the more developed applications, and lists additional immunotherapeutic drugs available on the Russian pharmaceutical market, including myelopid, polyoxydonium, licopid, diuciphon, viferon, and leukinferon. Species not specified; no original experimental data or numerical results were reported.
Abstract
In this manuscript an attempt is made to review the most important information pertinent to the main immunotropic preparations used now in different fields of clinical medicine. Numerous studies have confirmed high clinico-immunological efficiency of natural and synthetic thymus preparations: tactivin, thymalin, thymoptin, thymogen, thymomodulin, thymovocal, thymostimulin, thymopentin TP-5 and others. First of all, imidazole compounds, such as levamisol (decaris), dibazol, metromidazol are referred as synthetic preparations with positive action on T cell immunity. Recent data give an evidence that immunoglobulin isotypes IgM and IgG have normalizing effects on immunopathological processes. At present, we are in disposition for rather broad selection of IgG class immunoglobulins both from home and from foreign production. Interferon therapy is rather widely spread and used in various fields of medicine. There is a huge volume of scientific information, which gives the evidence about versatile immunotropic effects of INF, mainly, of immunomodulating character. At present, there are several approaches to control cytokine (CK) network in different pathological conditions: a) administration of CK as replacement therapy; b) administration of CK with therapeutic purpose; c) administration of monoclonal antibodies against CK and their receptors. The most well developed application is CK use in tumor processes. Arsenal of immunotherapeutic drugs on pharmaceutical market in Russia is rather extensive in possession today. The great contribution to design, development and production of many of them was made by Russian scientists. This is only a small list: myelopid, tactivin, polyoxydonium, licopid, diuciphon, viferon, leukinferon and so on.
pepmg summarizes the peer-reviewed literature and links to every source — it sells nothing, ships nothing, and gives no medical, dosing, or human-use guidance. Don't just trust this summary: follow the citation to its source and read it yourself. Research use only.