Study summary · research use only
[Investigation of insertion/deletion polymorphism of the ACE gene in stroke patients]
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This human study examined the insertion/deletion polymorphism of the ACE gene in Hungarian stroke patients. Blood samples from 173 healthy donors and 253 stroke patients were analyzed by PCR. Among healthy donors, the I/I allele was found in 20%, I/D in 52%, and D/D in 28%. D/D prevalence did not differ between donors and patients (28% vs 27%, odds ratio 0.88; under 50 years, odds ratio 1.00). No correlation was found between D/D and conventional risk factors, but one was found in young patients with D/D and hyperlipidemia or hyperfibrinogenemia. D/D prevalence was higher with family history of myocardial infarction, and low in the cardioembolic group. The authors concluded the polymorphism was not an independent stroke risk factor, though linked to risk in some young patients.
Abstract
This is the first Hungarian paper on the insertion/deletion polymorphism of ACE gene in stroke patients. According to literature data, the role of this polymorphism is controversial in the pathogenesis of stroke. The aim was to study the prevalence of the polymorphism in healthy persons and in stroke patients. Blood samples from 173 unrelated healthy donors and 253 stroke patients were investigated by polymerase chain reaction (PCR). PrevIous stroke was documented by CT or MRI and CDS. A routine questionnaire was used to study previous vascular events and the risk profile of patients. I/I allele was found in 20%, I/D 52% and D/D 28% in the healthy group. Prevalence of the pathologic D/D allele did not differ between healthy and patients group (28% and 27%, OR: 0.88, and in subgroup age under 50 years OR: 1.00). No correlation was found between D/D and conventional risk profile but a positivE correlation was found in young patients having D/D and hyperlipidemia (p < 0.05) and hyperfibrinogenemia (p < 0.05). D/D prevalence was found higher in patients with family anamnesis of myocardial infarction (p < 0.05). Very low prevalence of D/D allele was found in cardiogen embolic group (p > 0.05). The ACE polymorphism does not seem to be an independent risk factor for stroke. However, in young stroke patients with D/D allele, hyperlipidemia and/or hyperfibrinogenemia present very high risk for stroke.
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