Study summary · research use only
Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
This study describes a series of NN703 peptide analogues combining lysine mimetics with naphthyl- or biphenylalanine groups, tested in vitro in a rat pituitary cell assay and then in vivo in pigs at a single dose of 50 nmol/kg. The authors report that re-introducing certain structural elements of NN703 that had been removed during earlier optimization for oral absorption led to compounds with strong activity in both the in vitro and in vivo tests. Species: rat (in vitro) and pig (in vivo).
Abstract
A series of NN703 analogues with lysine mimetics combined with naphthyl- or biphenylalanine in the core has been prepared and tested in vitro in a rat pituitary cell based assay and subsequently in vivo in pigs in a single dose at 50 nmol/kg. Re-introduction of certain pharmacophores in the C-terminal of NN703, which were originally removed during optimisation for oral bioavailability, led to unexpectedly potent compounds in vitro as well as in vivo.
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