Study summary · research use only
Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone
Plain-language summary
Paraphrased from the published abstract below — not a verdict on whether anything works.
In this study of obese Zucker rats, researchers examined metabolic effects of AOD9604, a synthetic analogue of the lipolytic domain of human growth hormone. Daily oral treatment with AOD9604 (500 microg/kg body weight) for 19 days was associated with a reduction of over 50% in body weight gain (15.8 vs 35.6 g) compared with control animals, and adipose tissue from treated animals showed increased lipolytic activity. Unlike chronic treatment with intact human growth hormone, chronic AOD9604 treatment was not associated with reduced insulin sensitivity, as assessed with euglycemic clamp techniques. The authors suggest this hGH lipolytic-domain analogue may have potential for further development as an orally administered agent for obesity, based on this rat study.
Abstract
A synthetic analogue (AOD9604) of the lipolytic domain of human growth hormone (hGH) has been studied for its metabolic actions in obese Zucker rats. Daily treatment with an oral dose of AOD9604 of 500 microg/kg body weight for 19 days reduced over 50% (15.8 +/- 0.6 vs. 35.6 +/- 0.8 g) body weight gain of the animals in comparison with the control. The adipose tissues of the AOD9604--treated animals were found to have an increase in lipolytic activity. In contrast to chronic treatment with intact hGH, chronic treatment with AOD9604 showed no adverse effect on insulin sensitivity of the animals, as demonstrated with euglycemic clamp techniques. The results in the present study suggest that the analogue of the hGH lipolytic domain may have the potential to be developed into an orally usable and safe therapeutic agent for obesity.
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